That's the fundamental question the immensely talented Super Valid Designs asks in a recent video on YouTube. The answer – an emphatic near four-minute long song – uses over a dozen fully 3D printed musical instruments with zero digital effects or post-processing. This video gives a peek behind the curtain at the process, but the main show starts at 21m 40s. Alternatively, you can listen to it on popular music streaming platforms, too.
Some of the instrument files are available on their Printables profile, should you feel inspired.